THỨ TƯ,NGÀY 22 THÁNG 4, 2020

Chemicals for the Chicken Prepared within Large Temperatures and you may Cancer Exposure

Bởi Nguyễn Hoàng Phong

Cập nhật: 05/07/2022, 12:57

Chemicals for the Chicken Prepared within Large Temperatures and you may Cancer Exposure

Boffins found that high usage of well-complete, fried, or barbecued beef was in the increased dangers of colorectal (19–21), pancreatic (21–23), and you can prostate (twenty-four, 25) cancer

Heterocyclic amines (HCAs) and polycyclic fragrant hydrocarbons (PAHs) was toxins shaped whenever muscle mass meats, including animal meat, pork, seafood, otherwise poultry, try prepared having fun with high-temperature measures, for example pan frying otherwise barbecuing truly more an unbarred flames (1). In laboratory tests, HCAs and PAHs have been found to get mutagenic-which is, it produce alterations in DNA that enhance the chance of malignant tumors.

HCAs is molded when proteins (the inspiration from necessary protein), glucose, and you can creatine or creatinine (ingredients included in strength) perform at high temperatures. PAHs try designed when lbs and you will fruit juice of beef grilled directly over a heated surface otherwise open fire trickle onto the epidermis otherwise flame, causing fire and tobacco. The newest smoking contains PAHs you to definitely after that adhere to the outside out-of the fresh animal meat. PAHs is also molded through the other cooking processes, eg https://datingranking.net/cs/indonesiancupid-recenze/ puffing away from meat (1).

HCAs are not used in significant numbers into the edibles aside from meat prepared in the highest temperatures. PAHs can be found in most other smoked items, plus in cigarette smoke and you will automobile fatigue smoke.

The formation of HCAs and you may PAHs varies by the animal meat variety of, preparing means, and you will “doneness” top (unusual, medium, or well said). Regardless of the version of meats, although not, chicken cooked at high heat, particularly above three hundred ?F (as in cooking otherwise pan frying), or which can be ready for quite some time tend to means significantly more HCAs. Such as for instance, well-done, grilled, otherwise barbecued chicken and you will steak most of the has higher levels off HCAs. Cooking strategies you to establish beef in order to smoking sign up to PAH creation (2).

HCAs and PAHs be able to destroying DNA simply after they is metabolized by particular nutrients in your body, a method titled “bioactivation.” Studies have unearthed that the experience of them enzymes, which can disagree certainly one of some one, could be strongly related to this new cancer threats from the connection with such ingredients (3–9).

Populace research has not created a definitive outcomes of HCA and PAH exposure out-of prepared meat and you may cancer in humans

Studies have shown you to connection with HCAs and you may PAHs can lead to malignant tumors within the creature models (10). A number of studies, rats or rodents given a nourishment supplemented which have HCAs setup tumors of the breast, rectum, the liver, body, lung, prostate, or other areas (11–16). Rodents fed PAHs including set up cancers, along with leukemia and you can cancers of the digestive system and lungs (17). Yet not, the dosage of HCAs and you can PAHs found in these studies had been quite high-equivalent to tens of thousands of minutes brand new dosages that a person manage consume in the a regular diet plan.

You to definitely difficulties with carrying out like knowledge is the fact it can be tough to determine the exact amount of HCA and you will/or PAH visibility one becomes out of prepared chicken. Although weight-loss forms can provide a good estimates, they could not need all of the outline about preparing process you to definitely is needed to dictate HCA and PAH visibility levels. Simultaneously, personal adaptation regarding the passion out of enzymes one metabolize HCAs and PAHs ong those who absorb (take in) a similar number of such compounds. In addition to, some one was met with PAHs from other ecological offer, just restaurants.

Several epidemiologic research has put intricate surveys to look at participants’ beef use and you may cooking actions (18). Yet not, most other research has found no relationship having risks of colorectal (26) or prostate (27) cancers.

Inside 2015, a different committee out-of gurus convened by the Around the globe Company to have Look toward Malignant tumors (IARC) computed use of red meat are “probably carcinogenic so you can human beings” (Category 2A), established mostly into the studies throughout the epidemiologic training as well as on the good evidence regarding mechanistic degree. However, IARC failed to ending one HCAs and you may PAHs was in fact on the malignant tumors occurrence.

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